You may have an issue with the Nook similar to the issue I guessed you might have on ADE.
Try completely removing any authorization from the Nook
- plug in using USB
- start ADE
- using ctrl-shift-E to ADE (cmd-shift-E if on Mac) should remove authorization from the Nook
- restart ADE
- reauthorize the Nook. It may prompt automatically on the ADE restart, or you may need menu/Library/Authorize Device.