Not built-in.
There are utilities to help: for example see http://www.thefreedictionary.com/download.htm and http://files.db3nf.com/DA-Setup.exe
that will make that facility available on almost any application.
I haven't tried them.
They probably won't work for DRM books, because they probably rely on copy and paste.
You'd need one that did OCR on the screen and then linked to a dictionary: not that hard to do but I don't know of one.
If you are a bit technical you could set up http://sourceforge.net/projects/capture2text/files/Capture2Text/ to do it.